STUDY OF ANTIGENOTOXIC POTENTIAL OF THE ROSEHIP (ROSA MAJALIS HERRM.) OF THE FAMILY ROSACEAE

Аннотация

Increasing the body's resistance to various environmental pollutants' adverse effects is one of
medicine's essential tasks. In this regard, an active search for antimutagens to eliminate or weaken mutagens' effect
in the body is currently underway. One of the promising sources of antimutagenic compounds is the medicinal plant
Rosa majalis Herrm (rosehips). The genotoxic and antigenotoxic activity of rosehips was studied on cells of bone
marrow, spleen, liver, and kidneys of laboratory mice using an alkaline variant Comet assay. It was found that
rosehip infusions in various concentrations (infusion, diluted infusion and herbal tea) do not have a genotoxic effect
on the cells of the studied organs of laboratory animals. The medicinal rosehip's combined action with classical
mutagen MMS significantly reduced (p<0.01) MMS-induced mutagenesis level. The various rosehip infusions used
did not show statistically significant differences among themselves. The results obtained indicate the antigenotoxic
activity of R. majalis infusions.