ENCAPSULATION OF VITAMIN AEVIT OIL SOLUTION WITH β-CYCLODEXTRIN
Ключевые слова:
cyclodextrins, β-cyclodextrin, encapsulation, clathrate, vitamin.Аннотация
The present work aimed at encapsulation of fat-soluble vitamin Aevit (vitamins A and E, oil) with
β-cyclodextrin. Inclusion complex of vitamins A and E with β-cyclodextrin was prepared in an aqueous alcohol
medium by ultrasonic treatment. The surface morphology of the resulting clathrate inclusion complexes was
described using a scanning electron microscope. The results of thermographic measurements on a differential
scanning calorimeter are presented. The spectral properties of the inclusion complex are characterized by 1
H and 13C
NMR spectroscopy data. The experimental results confirmed the existence of a complex of inclusion of
β-cyclodextrin with vitamin Aevit (2:1). The activation energy of the thermooxidation destruction reaction of the
clathrate complex β-cyclodextrin:vitamin Aevit was calculated, kinetic parameters of thermal destruction of clathrate
were determined. These parameters were determined based on the Freeman-Carroll, Sharpe-Wentworth, Ahar and
Coates-Redfern methods. The use of the above models made it possible to graphically establish the thermodynamic
parameters of the thermal decomposition of β-cyclodextrin and its clathrate with vitamin. The data of thermographic
measurements on a differential scanning calorimeter showed that the thermal destruction of the Aevite clathrate with
β-cyclodextrin begins with the removal of water molecules from the β-cyclodextrin cavity, then the “guest”
substance and the cyclic oligosaccharide are destroyed.
