INFLUENCE ON HOMEOSTASIS AS THE CRITERION FOR SELECTING SINGLE NUCLEOTIDE POLYMORPHISMS FOR THE STUDY OF METABOLIC SYNDROM IN THE KAZAKH POPULATION

Аннотация

Metabolic syndrome (MS) is increasingly cited as the world's leading health risk. The sequence of
events toward multimorbidity in most cases passes through MS. According to the research, MS heritability ranges
from 23 to 27% in Europeans, and 51 to 60% in Asians.
The purpose of the review: to form a strategy for the selection of single nucleotide polymorphisms (SNPs) for
the study of MS in the Kazakh population based on the effect of SNPs on homeostasis indicators
The stable symptom complex of MS is a complicated dynamic system of successive accumulations of
dysmetabolic disorders of homeostasis. This system starts the development of subsequent age-associated diseases),
such as cardiometabolic, neurodegenerative, and malignant neoplasms.
The system for selecting SNPs for the MS study, proposed on the basis of the concept of homeostasis
dysfunction, assumes, in conditions of limited resources, to see the greatest level of their influence within the
conditional framework of three genetic models of homeostasis dysregulation: insulin resistance , oxidative stress, and
chronic inflammation. This approach is fundamentally different from the traditional approach involving candidate
genes. It is expected that scientific research in this direction will contribute not only to the understanding of general
biological processes, but also to the targeted search for genetic determinants and for new opportunities for
personalized interventions.