OBTAINING AND RESEARCH OF THE SUPRAMOLECULAR COMPLEXES OF ALKALOID SALSOLINE WITH CYCLODEXTRINS BY NMR SPECTROSCOPY

Аннотация

One-dimensional NMR 1
H, 13C and DEPT and two-dimensional spectroscopy COSY (1
H-1
H), 1
H-1
H
TOCSY, 1
H-1
H ROESY, HMQC (1
H-13C) and 1
H-13C HMBC were used to study the alkaloid salsoline, as well as its
supramolecular components, and the supramolecular components of the HMBC spectroscopy polysaccharides α- and
γ-cyclodextrins. Schemes of proton correlation with protons through three carbon atoms (1
H-1
H) and HMQC (1
H- 13C) in the initial state of the alkaloid under study. The use of the possibilities of two-dimensional spectroscopy
COSY (1
H-1
H), 1
H-1
H TOCSY, 1
H-1
H ROESY, HMQC (1
H-13C) and 1
H-13C HMBC when studying the alkaloid
under study correctly and uniquely identify the structure of the substrate of supramolecular self-assembly with cyclic
fields. Homonuclear and heteronuclear correlation NMR COSY (1
H-1
H) and HMQC (1
H-13C) are also used to
confirm the structure and structure of the cyclic polysaccharides of α- and γ-cyclodextrins. The chemical shifts of the
aliphatic and hydroxyl protons of the inner and outer surfaces of the receptors were determined. A comparative
analysis of the 1
H and 13C NMR spectra of salsoline, α- and γ-cyclodextrins and their supramolecular complexes was
carried out. Certain changes have the chemical shifts of 1
H and 13C nucleus of salsoline, as well as α- and γcyclodextrins in supramolecular complexes. The proton integral intensities of the substrate and receptors in the 1
H
NMR spectra were definitely that the supramolecular self-assembly with alpha and γ-cyclodecrins occurs with the
formation of complexes without including (external) due to the intermolecular interaction of hydroxyl groups from
both the alkaloids and cyclodextrins . The water-soluble aggregates formed during this process are capable of
solubilizing the required substrate through non-inclusive complexation.