HYDRAZIDE OF o-HYDROXYBENZOIC ACID AND ITS ERIVATIVES. SYNTHESIS AND PROPERTIES

Аннотация

The article presents the results of a study by the authors of the article on the development of new ways
of synthesis and study of the biological activity of hydrazide derivatives of o-hydroxybenzoic acid. Methods for the
preparation of hydrazone, oxadiazole, thiosemicarbazide, 1,2,4-triazole-3-thionic derivatives and methods for their
further modification are described. The condensation reaction of hydroxybenzoic acid hydrazides with 1-deoxy2,3,4,6-tetra-O-acetyl-D-glucopyranosyl isothiocyanate synthesized their corresponding acetylated glycosyl-containing thiosemicarbazide derivatives. The structures of the synthesized compounds were studied by 1
H and 13C NMR
spectroscopy, as well as by the data of two-dimensional spectra of COSY (1
H-1
H) and HMQC (1
H-13C). The values of
chemical shifts, multiplicity, and integrated intensity of 1H and 13C signals in one-dimensional NMR spectra were
determined. Using spectra in the formats COSY (1
Н-1
Н) and HMQC (1
Н-13С), homo- and heteronuclear interactions
were established, confirming the structure of the compounds under study. The results of evaluating their antimicrobial,
anti-inflammatory and cytotoxic activity (in vitro) on cultures of human monocytic cell lines MonoMac-6 and THP1Blue are described.